Pathophysiology of severe traumatic brain injury / Fisiopatología de la lesión cerebral traumática severa

Department of Neurosurgery University of Campinas

Texto completo:




  • Primary Injury: injury for the traumatic event itself, the direct impact in the neural tissue with ischemia, contusion and hemorrhage.

  • Secondary Injury: occurs after the primary injury that starts secondary cellular phenomena in the neural tissue:

    Early Phase: interruption of the blood flow with hypoxia

    Intermediary Phase: neuroinflammation, activation of the microglia

    Late Phase: regeneration and self-repair

  • Cerebral blood flow auto regulation, primary measures to treat ICP elevation and ICP monitoring in severe TBI are also described.

Palabras clave

Trauma craneoencefálico


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